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Research Progress of Autophagy-Related Regulatory Non-Coding RNAs in Acute Pancreatitis

LU Shihao^1,2#, WANG Qiong^1#, WANG Zhandong¹, HE Zening¹, ZHANG Yu¹, LIAN Yuan¹, LIU Xinhong³, WANG Yongfeng^1,4*, DONG Pengcheng^1,2,5*

(¹Gansu University of Chinese Medicine, Lanzhou 730000, China; ²Gansu Scientific Data Center for Laboratory Animals, Lanzhou 730050, China; ³Gansu Agricultural University, Lanzhou 730000, China; ⁴Gansu Medical College, Pingliang 744000, China; ⁵Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China)

Abstract:

AP (acute pancreatitis) is a prevalent inflammatory disorder of the gastrointestinal system for which, at present, no effective or specific therapeutic intervention is available. In recent years, accumulating evidences have indicated that dysregulated autophagy is closely associated with the pathogenesis and progression of AP, significantly influencing disease severity and clinical outcomes. During the development of AP, ncRNAs (noncoding RNAs) have emerged as critical regulators of autophagy. Current studies demonstrate that autophagy-related regulatory ncRNAs are deeply involved in the modulation of pancreatic tissue inflammation and cellular injury during the early stages of AP by regulating autophagic activity and efficiency. These ncRNAs play pivotal roles in controlling gene expression and the production of inflammatory cytokines. Despite these advances, the precise molecular mechanisms underlying the function of autophagy-related ncRNAs in AP remain to be fully elucidated, necessitating further investigation to identify novel therapeutic targets and strategies for AP management.

CSTR: 32200.14.cjcb.2026.05.0020